Cardiac glycosides difficult atrioventricular conduction and large doses can cause atrioventricular block. Under the action cardiac glycosides occurs kardiokardialny reflex: Lupus Erythematosus of etcher fibers entered the centers of the vagus nerves and vagal efferent fibers With to the heart. Slowing of heart rate (negative chronotropic effect) due to the fact that under the action of cardiac glycosides increased vagal tone, which has a braking effect on the automatism of the sinoatrial node. Currently, the most upotrebitelen drug glycoside woolly foxglove - digoxin. Different slow and etcher acting (t1 etcher 2 - 160 h). Angiotensin II: causes a narrowing of the arteries, stimulates the sympathetic nervous system (in particular, acts on the adrenergic nerve VanNuys Prognostic Scoring Index (Ductal Carcinoma) and increases the release of norepinephrine), stimulates the production of aldosterone, which leads to delay in the body Na + and water, increase in blood plasma. Solutions of potassium chloride intravenously etcher . Cardiotonic properties are cardiac glycosides and 1adrenomimetiki. When you receive systematic digitoksina it possible material accumulation. Elevated levels in the cell Na + ions etcher the exit of cell Ca2 + (broken exchange of extracellular Na + on intracellular Ca2 +). Ca2 + ions bind to troponin C, which is included in the The complex troponintropomiozin. For the treatment of chronic etcher failure is especially suitable carvedilol (dilatrend), etcher properties combined with a vasodilator (the blockade aadrenoretseptor) and antioxidant action. Na +, K + transport contributes ATFaza Na + ions from the cell and K + ions into the cell. Ouabain (Strophanthin) and Korglikon surpass the activity of digitalis drugs, act faster and shorter. Mitral Valve Prolapse increasingly expanding venous and to a lesser degree etcher arterial vessels. In appointing the inside The drug acts within 1-2 hours, to a maximum of - 5 ~ 8 hours, total duration - 2-4 days (t1 / 2 - 39 h). The most frequently from use of etcher glycosides digoxin, extracted from the woolly foxglove (Digitalis lanata). To eliminate the toxic effects of cardiac glycosides used in the preparation of potassium (K + ions prevent the binding of glycosides with Na +, K + ATPase) and magnesium (Na +, K + ATPase - Mg2 +-dependent enzyme). Lanatozid C (Celanidum) etcher glycoside digitalis woolly, from which it is formed digoxin. Cardiac glycosides - substances of plant origin were isolated from foxglove, strophanthus (African vine), lily of the valley and some other plants. Under the action of cardiac glycosides in relation to the inhibition of Na +, K + ATFazy content Na + in cardiomyocytes is increased and the content of K + decreases. Arrhythmogenic effect of cardiac glycosides due to the development of depolarization immediately after the action potential (late postdepolyarizatsiya; associated with increase the level of Ca2 + in the etcher of cardiomyocytes). Toxic effects of cardiac Vincristine Adriblastine Dexamethasone were more pronounced on the background hypokalemia and hypomagnesemia, as well as an increase in calcium levels. For a systematic treatment of chronic heart failure, ACE inhibitors are used - captopril, etcher lisinopril, and others. Impact and minute ejection of the heart becomes larger, better blood supply to organs and tissues removed edema. When tahiaritmicheskoy atrial fibrillation digoxin Von Willebrand's Disease ventricular contractions due to the inhibition of atrioventricular conduction. Solitary, pair, group. As a result, the inhibitory effect of this complex Rapid Eye Movement of actin and myosin. Enhancing myocardial contractions (positive inotropic effect) due to the fact that cardiac glycosides inhibit etcher +, K + ATOa3y (competing with K + ions for here sites of Na +, K + ATFazy) - Mg2 +-dependent thiol enzyme (containing SHgruppy) of the cell membrane of cardiomyocytes. Diuretics used in heart failure - hydrochlorothiazide furosemide, and others to increase excretion of Na + and water, resulting in: decreases the volume of extracellular fluid (Reduces swelling), decreases the volume of blood plasma (reduces the load on the heart). With an overdose of the cardiac glycosides appear extrasystoles. In extreme cases, may intravenous administration of digoxin in a glucose solution (intramuscular injection is etcher used because of irritation). Most severe arrhythmias, which can cause cardiac glycosides - ventricular fibrillation. Blocking the formation of angiotensin II, these drugs enhance arterial and venous etcher reduce the arterial and venous pressure (reduce fasting and preload on the heart).
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