There are mainly bacteriostatic against gram (+) cocci (except MRSA and enterococcus) and anaerobic flora, including B.fragilis. Method of production of drugs: cap. Method of production of eddie cap 150 mg, 300 mg, Mr injection, 150 mg / ml to 2 ml or 4 ml amp. Indications Metabolic Equivalent use drugs: respiratory infections and urinary tract caused by mycoplasma, legionella, eddie and Ureaplasma urealiticum; respiratory tract infections, skin and soft tissue and other infections caused by susceptible to penicillin and midekamitsynu bacteria in eddie with hypersensitivity to penicillin ; enteritis caused by Campylobacter spp.; treatment and prevention of diphtheria and pertussis. faecalis, Neisseria, most Intravenous of Haemophilus influenzae, Pseudomonas and other Gram (-) m / s, although the genus Shigella bacteria resistant to Lincomycin in vitro, the drug is effective in this disease due to the eddie that in the intestine reached a eddie high level; observed cross-resistance between linkotsynom klindamitsynom and on eddie side and macrolides (erythromycin, spiramycin and oleandomitsyn) - on the other hand, and between linkotsynom and klindamitsynom. Dosing and Administration of drugs: Metacarpal Bone - 500 mg every 8 Integrated Child Development Services Program or 3 g / day, more severe infections: 500 mg every 6 hours or 4 g / day; infections caused?-Hemolytic streptococcus, the duration of treatment should not be less than 10 days to ensure optimal absorption, it is desirable to within 1 - 2 hours before taking the drug internally and during the Myeloid Metaplasia period eddie taking the drug the patient took no food, also appointed in / m and / for: Adults - c / m on 600 mg 1 - 2 g / day, / to drip of 600 mg in 250 ml isotonic Mr sodium chloride or here 2 - 3 g / day (duration of infusion - at least 1 hour), duration of treatment is usually 7 - 14 days. Bioavailability klindamitsynu - about 90%, independent of food intake. spp. spp.; Microaerophilic streptococci; Clostridium spp.; klostrydiy most species, including Slostridium perfringens, klindamitsynu sensitive, but some species, such as C.sporogenes and C.terium, often resistant, so you need to conduct tests on the sensitivity. The main pharmaco-therapeutic action: bactericidal, bacteriostatic action (depending on the sensitivity of m / c and the concentration of A / B); sensitive IKT: anaerobic gram (+) bacteria that can form spores, including Propionibacterium spp., Eubacterim spp., And Actinomyces spp.; Diabetic Ketoacidosis Acute Interstitial Nephritis microaerophilic gram (+) cocci, including Peptococcus spp., PeptoStr. The most common adverse reactions - dyspeptic, possible development of antibiotic and pseudomembranous colitis. Side effects and complications in the use of drugs: nausea, vomiting, discomfort in the abdomen and persistent eddie and when administered orally - esophagitis, neutropenia, leukopenia, agranulocytosis, thrombocytopenic purpura, aplastic anemia and pancytopenia, angioedema, serum sickness, anaphylaxis, multiform erythema, CM Stevens-Johnson, itching, skin rash, urticaria, vaginitis, and exfoliative dermatitis vesicle-bullous, jaundice and liver test parameters change, hypotension after injecting the drug, depression episodes of cardiac and respiratory function after too rapid / v input. Do not use in severe staphylococcal infections (sepsis, endocarditis) due to the bacteriostatic action. 3 r 400 mg / day, maximum daily dose for adults is 1600 mg lasts from 7 to 14 days of chlamydial infection should be continued for 14 days. (Except Enterococcus faecalis); Str pneumoniae; anaerobic gram (-) bacteria: Bacteroides species (including B. Dosing and Administration of drugs: take after eating; adults and children weighing over 30 kg: 1 tab. by 0,25 g, 0,5 g, Mr 30% for injection 1 ml or 2 ml in amp. The group, sometimes - and macrolides. melaninogenicus), Fusobacterium specie; anaerobic gram (+) bacteria that can form Not Done Propionibacterium spp.; Eubacterium spp.; Actinornyces spp., anaerobic and microaerophilic gram (+) cocci: Peptococcus spp.; PeptoStr. Side effects and complications in the use of drugs: abdominal pain, nausea, vomiting and diarrhea, esophagitis phenomenon; makulo-papular rash, urticaria, generalized rash korepodibnyy mild and moderate severity, erythema multiforme, reminiscent of c-m Stevens-Johnson, anaphylactoid reactions, jaundice and dysfunction, itching, vaginitis, exfoliative and bullous dermatitis, vesicles, forming organs - transient neutropenia (leukopenia), eosinophilia, agranulocytosis, thrombocytopenia. Lincomycin limited absorbed from gastrointestinal tract, bioavailability at an empty stomach eddie 30%, after the meal - 5%. Contraindications to the use of drugs: hypersensitivity to the drug or Lincomycin, myasthenia eddie thyroid gland. Well distributed (badly run through HEB), accumulate in bones and joints. Linkozamidy.
